Lasers in Dermatology and Medicine by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9783319761183
Publisher: Springer International Publishing

Photodynamic Therapy (PDT)

PDT uses IPL as a light source which stimulates severely photodamaged skin (as in photorejuvenation) and destroys pre-malignant cells in actinic keratosis and basal cell carcinomas via activation of a photosensizer [32]. Topical administration of 5-aminolevulinic acid [5-ALA] or its methyl ester induces formation of protoporphyrin IX which photosensitizes the target area prior to IPL irradiation. The IPL light leads to the production of activated oxygen species within photodamaged cells, resulting in their destruction. The photosensitizer is applied between 30 min and 3 h prior to IPL irradiation. Indications for PDT include photorejuvenation, precancer and nonmelanoma skin cancer, such as actinic keratosis, superficial basal cell carcinoma, and Bowen’s disease. Side effects include pain during irradiation, erythema, edema, and crusting for up to a week, and subsequent hyperpigmentation, especially in darker skin types. Depending on the photosensitizer used, treatment size, and lesion type, side effects may be more or less severe. In general, PDT is well tolerated and can be used to treat multiple areas simultaneously.

Download

Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.